• Loading dosage in status epilepticus (unlicensed indication)
• Status epilepticus where phenytoin is inappropriate due to:
  • contraindications (2^nd and 3^rd degree heart block; sino-atrial block; sinus bradycardia; Stokes-Adams syndrome)
  • stroke history
  • interacting medications - especially DOACs (apixaban, edoxaban, rivaroxaban and dabigatran)

• Loading dose of levetiracetam does not require adjustment in patients with impaired renal function. Use doses indicated in Table 1 irrespective of eGFR

• Levetiracetam injection 100 mg/mL in 5 mL (500 mg) ampoules

• Sodium chloride 0.9%, glucose 5%, Hartmann’s

• Levetiracetam 60 mg/kg by IV infusion up to a maximum of 4500 mg (see Table 1 for dose by weight-band)
• Dilute required dose in ≥100 mL of suitable diluent (see Diluents above) and give by IV over 15 min

Table 1: Weight-banded loading dose of levetiracetam (60 mg/kg)